Ejaculatory Duct Obstruction Affects Seminal Vesicle Contractile Efficacy and Smooth Muscle Ultrastructure in a Rat Model

نویسندگان

چکیده

The purpose of this study was to investigate the effects ejaculatory duct obstruction (EDO) on contractile efficacy, smooth muscle ultrastructure, and α1A M3 receptors rat seminal vesicles (SVs). A total 48 male rats, aged 14-15 weeks, were randomly divided into three groups, namely, control, complete EDO, partial EDO. SV tissues collected at 4 8 weeks postoperatively for further experiments. Results revealed a marked reduction in efficacy over time following EDO group. force frequency decreased increased group week 4, respectively, whereas significantly reduced 8. Moreover, resulted significant downregulation expression proteins mRNAs rats from time. Rats initially exhibited an increase followed by decrease. Analysis ultrastructure muscles confirmed above changes. In conclusion, can lead progressive decrease efficiency SVs. On other hand, first compensate contraction SVs gradually decompensate afterwards.

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ژورنال

عنوان ژورنال: Andrologia

سال: 2023

ISSN: ['0303-4569', '1439-0272']

DOI: https://doi.org/10.1155/2023/5022466